Sulfuric Acid → HCID 19378710, compound

HRID 2210424Notes

Reaction equation

HRID 2210424 reaction equation
O.NC1[NH:8][C:7]2[CH:9]=[C:10]([Cl:13])[N:11]=[CH:12][C:6]=2[S:5](=[O:15])(=[O:14])[N:4]=1.OS(O)(=O)=O.C([O-])(O)=O.[Na+]>O>[NH2:8][C:7]1[C:6]([S:5]([NH2:4])(=[O:15])=[O:14])=[CH:12][N:11]=[C:10]([Cl:13])[CH:9]=1

Participants

5

Reactant 3

HCID 1118Sulfuric AcidHCID 516892Sodium BicarbonateHCID 19378724HCID 19378724, compound

Product 1

HCID 19378710HCID 19378710, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 1 g of 3-amino-6-chloro-4H- pyrido[4,3-e][1,2,4]thiadiazine 1,1-dioxide monohydrate (compound obtained in Example 31 below) in 30 cm3 of 50% v/v H2SO4 in water is brought to reflux for 15 minutes. After cooling, the solution is thinned down with 300 cm3 of ice-cold water and then neutralized to a pH of 7 using solid NaHCO3. The white crystalline precipitate obtained is collected on a filter, washed with water and dried.

Workup

  1. temperatureto reflux for 15 minutes
  2. temperatureAfter cooling
  3. customThe white crystalline precipitate obtained
  4. customis collected on a filter
  5. washwashed with water
  6. customdried

Sources & evidence

ORD record
ord-5149a814ad5444ce8998a7fbef17d539
Source dataset
uspto-grants-1995_10
Patent number
US05459138

Reaction notes

Loading…