Ammonium Chloride → 3-Amino-5-methylpyridine-2-sulfonamide

Participants

Reaction Steps

3.46 g of reduced iron and 0.53 g of ammonium chloride are added to a solution of 2.17 g of 5-methyl-3- nitropyridine-2-sulfonamide in 60 cm3 of water/alcohol (EtOH/H2O : 1/1) solution. The mixture is brought to reflux for 20 minutes and then filtered while hot. The filtrate is concentrated to a small volume and left at 4° C. for 12 hours. The crystalline precipitate obtained is collected on a filter, washed with water and dried.

Provenance & Evidence