HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2,3-DIHYDRO-4H-PYRIDO[3,2-e] [1,2,4]THIADIAZINE 1,1-DIOXIDE
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | 3-Aminopyridine-2-sulfonamide | HCID 14943702 | — |
| Catalyst | Ethyl Acetate | HCID 8857 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 2,3-DIHYDRO-4H-PYRIDO[3,2-e] [1,2,4]THIADIAZINE 1,1-DIOXIDE | HCID 10821380 | — |
Reaction Steps
A mixture of 1 g of 3-aminopyridine-2-sulfonamide (Preparation 1) and 0.23 g of paraformaldehyde (1.3 eq.) in 10 cm3 of isopropanol to which 10 drops of ethyl acetate saturated with gaseous HCl have been added is brought to reflux for 1 to 2 hours. After cooling, the crystalline precipitate of the title compound is collected on a filter and washed with isopropanol. The product is recrystallized from hot water.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05459138 |
| Source dataset | uspto-grants-1995_10 |
| ORD ID | ord-8c020f08879e406289981aedab0ad706 |
| Source note | uspto-grants-1995_10 |