反应详情

A mixture of 1 g of 3-aminopyridine-2-sulfonamide (Preparation 1) and 0.23 g of paraformaldehyde (1.3 eq.) in 10 cm3 of isopropanol to which 10 drops of ethyl acetate saturated with gaseous HCl have been added is brought to reflux for 1 to 2 hours. After cooling, the crystalline precipitate of the title compound is collected on a filter and washed with isopropanol. The product is recrystallized from hot water.

1. additionhave been added
2. temperatureto reflux for 1 to 2 hours
3. temperatureAfter cooling
4. customthe crystalline precipitate of the title compound is collected on
5. filtrationa filter
6. washwashed with isopropanol
7. customThe product is recrystallized from hot water