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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2210441Generated: October 30, 2026

p-Toluenesulfonic acid → 3-Methyl-4H-pyrido[3,2-e]-1,2,4-thiadiazine 1,1-

https://huagongshe.com/reaction/2210441

Reaction equation

Participants

RoleNameHCIDCharge
Reactantp-Toluenesulfonic acidHCID 6101—
Reactant3-Aminopyridine-2-sulfonamideHCID 14943702—
SolventEthyl ortho-acetateHCID 86598186—
Product3-Methyl-4H-pyrido[3,2-e]-1,2,4-thiadiazine 1,1-HCID 10081414—

Reaction Steps

1 g of 3-aminopyridine-2-sulfonamide (Preparation 1) and 1 g of p-toluenesulfonic acid are dissolved in 6 cm3 of ethyl orthoacetate. After 10 minutes at room temperature, the precipitate obtained is collected on a filter, washed with diethyl ether and dried. It is recrystallized from hot water.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05459138
Source datasetuspto-grants-1995_10
ORD IDord-df9841b9402b4bc596650951f1734a27
Source noteuspto-grants-1995_10