p-Toluenesulfonic acid → 3-Methyl-4H-pyrido[3,2-e]-1,2,4-thiadiazine 1,1-

HRID 2210441Notes

Reaction equation

HRID 2210441 reaction equation
[NH2:1][C:2]1[C:3]([S:8]([NH2:11])(=[O:10])=[O:9])=[N:4][CH:5]=[CH:6][CH:7]=1.[C:12]1(C)C=CC(S(O)(=O)=O)=C[CH:13]=1>C([O-])([O-])(OCC)C>[CH3:12][C:13]1[NH:1][C:2]2[CH:7]=[CH:6][CH:5]=[N:4][C:3]=2[S:8](=[O:10])(=[O:9])[N:11]=1

Participants

4

Reactant 2

HCID 6101p-Toluenesulfonic acidHCID 149437023-Aminopyridine-2-sulfonamide

Product 1

HCID 100814143-Methyl-4H-pyrido[3,2-e]-1,2,4-thiadiazine 1,1-

Reagents, catalysts & solvents 1

HCID 86598186Ethyl ortho-acetateSolvent

Procedure

1 g of 3-aminopyridine-2-sulfonamide (Preparation 1) and 1 g of p-toluenesulfonic acid are dissolved in 6 cm3 of ethyl orthoacetate. After 10 minutes at room temperature, the precipitate obtained is collected on a filter, washed with diethyl ether and dried. It is recrystallized from hot water.

Workup

  1. customthe precipitate obtained
  2. customis collected on a filter
  3. washwashed with diethyl ether
  4. customdried
  5. customIt is recrystallized from hot water

Sources & evidence

ORD record
ord-df9841b9402b4bc596650951f1734a27
Source dataset
uspto-grants-1995_10
Patent number
US05459138

Reaction notes

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