Acetic Anhydride → HCID 10012589, compound

HRID 2210442Notes

Reaction equation

HRID 2210442 reaction equation
[C:1](OC(=O)C)(=O)C.[NH2:8][C:9]1[CH:14]=[CH:13][N:12]=[CH:11][C:10]=1[S:15]([NH2:18])(=[O:17])=[O:16]>C(O)=O>[S:15]1(=[O:17])(=[O:16])[C:10]2[CH:11]=[N:12][CH:13]=[CH:14][C:9]=2[NH:8][CH:1]=[N:18]1

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 109759664-Amino-3-pyridinesulfonamide

Product 1

HCID 10012589HCID 10012589, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

3.3 cm3 of formic acid and 6.6 cm3 of acetic anhydride are kept stirring at 50° C. for 15 minutes. 1 g of 4-aminopyridine-3-sulfonamide (Preparation 2) is added to this solution and the reaction mixture is brought to reflux for 2 hours. After cooling, the crystals obtained are collected on a filter, washed with a small amount of acetic acid and then with diethyl ether and dried.

Workup

  1. temperatureto reflux for 2 hours
  2. temperatureAfter cooling
  3. customthe crystals obtained
  4. customare collected on a filter
  5. washwashed with a small amount of acetic acid
  6. dry with materialwith diethyl ether and dried

Sources & evidence

ORD record
ord-6cfb3c6c4516407d93ebda676993af92
Source dataset
uspto-grants-1995_10
Patent number
US05459138

Reaction notes

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