Propionic anhydride → HCID 10798543, compound

HRID 2210445Notes

Reaction equation

HRID 2210445 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1[S:8]([NH2:11])(=[O:10])=[O:9].[C:12](OC(=O)CC)(=O)[CH2:13][CH3:14]>C(OCC)C>[CH2:13]([C:14]1[NH:1][C:2]2[CH:7]=[CH:6][N:5]=[CH:4][C:3]=2[S:8](=[O:10])(=[O:9])[N:11]=1)[CH3:12]

Participants

4

Reactant 2

HCID 31263Propionic anhydrideHCID 109759664-Amino-3-pyridinesulfonamide

Product 1

HCID 10798543HCID 10798543, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Conditions

Temperature
150 °C

Procedure

A mixture of 1 g of 4-aminopyridine-3-sulfonamide (Preparation 2) and 10 cm3 of propionic anhydride is heated at 150° C. for 8 hours. After cooling, an equal volume of diethyl ether is added and the precipitate obtained is collected on a filter, washed with diethyl ether and dried. It is recrystallized from hot water.

Workup

  1. temperatureAfter cooling
  2. customthe precipitate obtained
  3. customis collected on a filter
  4. washwashed with diethyl ether
  5. customdried
  6. customIt is recrystallized from hot water

Sources & evidence

ORD record
ord-a935924d49f34fc78f6f23d7d48af723
Source dataset
uspto-grants-1995_10
Patent number
US05459138

Reaction notes

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