Methyl iodide → HCID 10012941, compound

HRID 2210457Notes

Reaction equation

HRID 2210457 reaction equation
C(=O)([O-])[O-].[K+].[K+].I[CH3:8].[S:9]1(=[O:20])(=[O:19])[C:14]2[N:15]=[CH:16][CH:17]=[CH:18][C:13]=2[NH:12][CH:11]=[N:10]1>C(#N)C>[CH3:8][N:12]1[C:13]2[CH:18]=[CH:17][CH:16]=[N:15][C:14]=2[S:9](=[O:20])(=[O:19])[N:10]=[CH:11]1

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 9989901HCID 9989901, compound

Product 1

HCID 10012941HCID 10012941, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Conditions

Temperature
50 °C

Procedure

1.2 g of potassium carbonate and 1.37 g of iodomethane are added to a solution of 0.6 g of 4H- pyrido[3,2-e][1,2,4]thiadiazine 1,1-dioxide (Example 16) in 15 cm3 of acetonitrile. The suspension is heated at 50° C. for 3 hours. The acetonitrile is then removed by evaporation under partial vacuum. The residue is taken up in 20 cm3 of water. The title product, which has little solubility in water, is collected on a filter, washed with water and dried.

Workup

  1. customThe acetonitrile is then removed by evaporation under partial vacuum
  2. customis collected on a filter
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-156a5217a2d74b548dd5adda7877db36
Source dataset
uspto-grants-1995_10
Patent number
US05459138

Reaction notes

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