Sodium borohydride → HCID 10631839, compound

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Reaction Steps

0.08 g of NaBH4 is added to a solution of 0.1 g of 4-methyl-4H-pyrido[3,2-e][1,2,4]thiadiazine 1,1- dioxide (Example 63) in 6 cm3 of isopropanol. The mixture is kept stirring at ambient temperature for 45 minutes. The solvent is then removed under partial vacuum and the residue is treated with 5 cm3 of water. The suspension obtained is adjusted to a pH of 7 and then extracted with chloroform (3 times 100 cm3). The organic phase is washed with water (25 cm3), dried (MgSO4) and then concentrated to dryness to provide the title compound.

Provenance & Evidence