Sodium borohydride → HCID 10631839, compound

HRID 2210458Notes

Reaction equation

HRID 2210458 reaction equation
[BH4-].[Na+].[CH3:3][N:4]1[C:9]2[CH:10]=[CH:11][CH:12]=[N:13][C:8]=2[S:7](=[O:15])(=[O:14])[N:6]=[CH:5]1>C(O)(C)C>[CH3:3][N:4]1[C:9]2[CH:10]=[CH:11][CH:12]=[N:13][C:8]=2[S:7](=[O:15])(=[O:14])[NH:6][CH2:5]1

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 10012941HCID 10012941, compound

Product 1

HCID 10631839HCID 10631839, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

0.08 g of NaBH4 is added to a solution of 0.1 g of 4-methyl-4H-pyrido[3,2-e][1,2,4]thiadiazine 1,1- dioxide (Example 63) in 6 cm3 of isopropanol. The mixture is kept stirring at ambient temperature for 45 minutes. The solvent is then removed under partial vacuum and the residue is treated with 5 cm3 of water. The suspension obtained is adjusted to a pH of 7 and then extracted with chloroform (3 times 100 cm3). The organic phase is washed with water (25 cm3), dried (MgSO4) and then concentrated to dryness to provide the title compound.

Workup

  1. customThe solvent is then removed under partial vacuum
  2. additionthe residue is treated with 5 cm3 of water
  3. customThe suspension obtained
  4. extractionextracted with chloroform (3 times 100 cm3)
  5. washThe organic phase is washed with water (25 cm3)
  6. dry with materialdried (MgSO4)
  7. concentrationconcentrated to dryness

Sources & evidence

ORD record
ord-94faf1161ed6413db6667d36558aac8c
Source dataset
uspto-grants-1995_10
Patent number
US05459138

Reaction notes

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