Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Propanal | HCID 527 | — |
| Reactant | HCID 15365170 | HCID 15365170 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 10823182 | HCID 10823182 | — |
Reaction Steps
A solution of 0.5 g of 4-methylaminopyridine-3- sulfonamide (Preparation 12) and 0.9 cm3 of propionaldehyde in 5 cm3 of isopropanol, to which 3 drops of a saturated solution of hydrochloric acid in ethyl acetate have been added, is heated for 3 hours at 50° C. The solvent is then removed under partial vacuum and the residue obtained is recrystallized several times from a chloroform/petroleum ether (1/3) mixture.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05459138 |
|---|
| Source dataset | uspto-grants-1995_10 |
|---|
| ORD ID | ord-21e089b901584f85ac40d58e6815c8bf |
|---|
| Source note | uspto-grants-1995_10 |
|---|
