Hydrochloric Acid → HCID 10823182, compound

HRID 2210460Notes

Reaction equation

HRID 2210460 reaction equation
[CH3:1][NH:2][C:3]1[CH:8]=[CH:7][N:6]=[CH:5][C:4]=1[S:9]([NH2:12])(=[O:11])=[O:10].[CH:13](=O)[CH2:14][CH3:15].Cl>C(O)(C)C.C(OCC)(=O)C>[CH2:14]([CH:13]1[N:2]([CH3:1])[C:3]2[CH:8]=[CH:7][N:6]=[CH:5][C:4]=2[S:9](=[O:11])(=[O:10])[NH:12]1)[CH3:15]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 527PropanalHCID 15365170HCID 15365170, compound

Product 1

HCID 10823182HCID 10823182, compound

Reagents, catalysts & solvents 2

HCID 3776IsopropanolSolventHCID 8857Ethyl AcetateSolvent

Conditions

Temperature
50 °C

Procedure

A solution of 0.5 g of 4-methylaminopyridine-3- sulfonamide (Preparation 12) and 0.9 cm3 of propionaldehyde in 5 cm3 of isopropanol, to which 3 drops of a saturated solution of hydrochloric acid in ethyl acetate have been added, is heated for 3 hours at 50° C. The solvent is then removed under partial vacuum and the residue obtained is recrystallized several times from a chloroform/petroleum ether (1/3) mixture.

Workup

  1. customThe solvent is then removed under partial vacuum
  2. customthe residue obtained
  3. customis recrystallized several times from a chloroform/petroleum ether (1/3) mixture

Sources & evidence

ORD record
ord-21e089b901584f85ac40d58e6815c8bf
Source dataset
uspto-grants-1995_10
Patent number
US05459138

Reaction notes

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