Sodium borohydride → HCID 19378714, compound

HRID 2210465Notes

Reaction equation

HRID 2210465 reaction equation
[CH3:1][N:2]1[C:7]2[CH:8]=[C:9]([CH3:12])[CH:10]=[N:11][C:6]=2[S:5](=[O:14])(=[O:13])[N:4]=[CH:3]1.[BH4-].[Na+]>C(O)(C)C.C(Cl)(Cl)Cl>[CH3:1][N:2]1[C:7]2[CH:8]=[C:9]([CH3:12])[CH:10]=[N:11][C:6]=2[S:5](=[O:14])(=[O:13])[NH:4][CH2:3]1

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 19378707HCID 19378707, compound

Product 1

HCID 19378714HCID 19378714, compound

Reagents, catalysts & solvents 1

HCID 21906603Chloroform isopropyl alcoholSolvent

Procedure

A solution of 0.5 g of 4,6-dimethyl-4H- pyrido[3,2-e][1,2,4]thiadiazine 1,1-dioxide (Example 76) in 25 cm3 of a 1/1 isopropanol/chloroform mixture is treated, in small portions, with 0.4 g of sodium borohydride with good stirring and under an inert atmosphere. After 30 minutes at ambient temperature, the excess borohydride is destroyed by addition of a few drops of acetic acid and the solvent is removed under reduced pressure. The residue is taken up in 10 cm3 of water and the pH of the mixture is brought to neutrality. The precipitate obtained is collected on a filter, washed with water and dried.

Workup

  1. customthe excess borohydride is destroyed by addition of a few drops of acetic acid
  2. customthe solvent is removed under reduced pressure
  3. customThe precipitate obtained
  4. customis collected on a filter
  5. washwashed with water
  6. customdried

Sources & evidence

ORD record
ord-5c8b179f691c4c51a9490c5c8681b0be
Source dataset
uspto-grants-1995_10
Patent number
US05459138

Reaction notes

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