Sodium borohydride → HCID 19378714, compound

Participants

Reaction Steps

A solution of 0.5 g of 4,6-dimethyl-4H- pyrido[3,2-e][1,2,4]thiadiazine 1,1-dioxide (Example 76) in 25 cm3 of a 1/1 isopropanol/chloroform mixture is treated, in small portions, with 0.4 g of sodium borohydride with good stirring and under an inert atmosphere. After 30 minutes at ambient temperature, the excess borohydride is destroyed by addition of a few drops of acetic acid and the solvent is removed under reduced pressure. The residue is taken up in 10 cm3 of water and the pH of the mixture is brought to neutrality. The precipitate obtained is collected on a filter, washed with water and dried.

Provenance & Evidence