Hydrochloric Acid → HCID 19378762, compound

HRID 2210478Notes

Reaction equation

HRID 2210478 reaction equation
C([O:3][C:4]([C:6]1[NH:11][C:10](=[O:12])[C:9]([CH2:13][CH:14]([CH3:16])[CH3:15])=[N+:8]([O-])[C:7]=1[O:18][CH3:19])=[O:5])C.[OH-].[Na+].Cl>CO>[CH2:13]([C:9]1[C:10](=[O:12])[NH:11][C:6]([C:4]([OH:5])=[O:3])=[C:7]([O:18][CH3:19])[N:8]=1)[CH:14]([CH3:16])[CH3:15]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 19378763HCID 19378763, compound

Product 1

HCID 19378762HCID 19378762, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

932 Milligrams of 6-ethoxycarbonyl-3-isobutyl-5-methoxy-1,2-dihydropyrazin-2-one 4-oxide in 21 ml of methanol and 10 ml of an aqueous solution of 1N-sodium hydroxide were mixed and stirred at room temperature for hours. The reaction mixture was acidified by adding hydrochloric acid, and the precipitated crystals were collected by filtration, and the crystals were dissolved in chloroform-methanol, next the solvent was removed by distillation to obtain 830 mg of 3-isobutyl-5-methoxy-1,2-dihydropyrazin-2-one-6-carboxylic acid 4oxide.

Workup

  1. filtrationthe precipitated crystals were collected by filtration
  2. dissolutionthe crystals were dissolved in chloroform-methanol, next the solvent
  3. customwas removed by distillation

Sources & evidence

ORD record
ord-0639d46671904c0da3a4cd1766e4bc75
Source dataset
uspto-grants-1995_10
Patent number
US05459142

Reaction notes

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