Lithium hydroxide, monohydrate → HCID 15293900, compound

HRID 2210566Notes

Reaction equation

HRID 2210566 reaction equation
[CH2:1]([C:5]1[N:6]([CH2:19][C:20]2[CH:25]=[CH:24][C:23]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=3[C:32]([C:34]([O:36]C)=[O:35])=[O:33])=[CH:22][CH:21]=2)[C:7]([C:14]([O:16]CC)=[O:15])=[C:8]([C:10]([OH:13])([CH3:12])[CH3:11])[N:9]=1)[CH2:2][CH2:3][CH3:4].O.[OH-].[Li+]>>[CH2:1]([C:5]1[N:6]([CH2:19][C:20]2[CH:21]=[CH:22][C:23]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=3[C:32]([C:34]([OH:36])=[O:35])=[O:33])=[CH:24][CH:25]=2)[C:7]([C:14]([OH:16])=[O:15])=[C:8]([C:10]([OH:13])([CH3:11])[CH3:12])[N:9]=1)[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 19378996HCID 19378996, compound

Product 1

HCID 15293900HCID 15293900, compoundYield 70.9%

Procedure

Following a procedure similar to that described in Example 1(b), but using 878 mg of ethyl 2-butyl-4-(1-hydroxy-1-methylethyl)-1-[(2'-methoxalylbiphenyl-4-yl)methyl]imidazole-5-carboxylate [prepared as described in step (a) above] and 364 mg of lithium hydroxide monohydrate, 571 mg of the title compound were obtained as a powder, softening at 140° C. and melting at 165°-170° C.

Sources & evidence

ORD record
ord-d053b1f26af14338bf9b05802ebd694c
Source dataset
uspto-grants-1995_10
Patent number
US05459148

Reaction notes

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