Lithium hydroxide, monohydrate → HCID 178440071, compound

HRID 2210568Notes

Reaction equation

HRID 2210568 reaction equation
[OH:1][C:2]([C:5]1[N:6]=[C:7]([CH2:34][CH2:35][CH3:36])[N:8]([CH2:15][C:16]2[CH:21]=[CH:20][C:19]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=3[C:28](=[O:33])[C:29]([O:31]C)=[O:30])=[CH:18][CH:17]=2)[C:9]=1[C:10]1[NH:14][N:13]=[N:12][N:11]=1)([CH3:4])[CH3:3].O.[OH-].[Li+]>>[OH:1][C:2]([C:5]1[N:6]=[C:7]([CH2:34][CH2:35][CH3:36])[N:8]([CH2:15][C:16]2[CH:17]=[CH:18][C:19]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=3[C:28](=[O:33])[C:29]([OH:31])=[O:30])=[CH:20][CH:21]=2)[C:9]=1[C:10]1[NH:14][N:13]=[N:12][N:11]=1)([CH3:4])[CH3:3]

Participants

3

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 178440072HCID 178440072, compound

Product 1

HCID 178440071HCID 178440071, compoundYield 54.3%

Procedure

Following a procedure similar to that described in Example 1(b), but using 180 mg of methyl {4'-[4-(1-hydroxy-1-methylethyl)-2-propyl-5-(tetrazol-5-yl)imidazol-1-ylmethyl]biphenyl-2-yl}glyoxylate [prepared as described in step (b) above] and 77 mg of lithium hydroxide monohydrate, 95 mg of the title compound, melting at 169°-170°C., were obtained.

Sources & evidence

ORD record
ord-20ffcfdf25424eb0b21583ea21ea4426
Source dataset
uspto-grants-1995_10
Patent number
US05459148

Reaction notes

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