Sodium Hydroxide → HCID 19378983, compound

HRID 2210573Notes

Reaction equation

C([C:5]1[N:6]([CH2:17][C:18]2[CH:23]=[CH:22][C:21]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=3[C:30]([C:32]([O:34]C)=[O:33])=[O:31])=[CH:20][CH:19]=2)[C:7]([C:15]#[N:16])=[C:8]([CH:10]([OH:14])[CH:11]([CH3:13])[CH3:12])[N:9]=1)CCC.[OH-:36].[Na+]>>[CH2:15]([NH:16][C:15]([C:7]1[N:6]([CH2:17][C:18]2[CH:19]=[CH:20][C:21]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=3[C:30]([C:32]([OH:34])=[O:33])=[O:31])=[CH:22][CH:23]=2)[CH:5]=[N:9][C:8]=1[CH:10]([OH:14])[CH:11]([CH3:13])[CH3:12])=[O:36])[CH2:7][CH2:8][CH3:10]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 19378948HCID 19378948, compound

Product 1

HCID 19378983HCID 19378983, compound

Procedure

245 mg of 2-butyl-4-(1-hydroxy-2-methylpropyl)-1-[(2'-methoxalylbiphenyl-4-yl)methyl]imidazole-5-carbonitrile [prepared as described in step (a) above] were subjected to hydrolysis using 6 ml of a 1N aqueous solution of sodium hydroxide in the same manner as described in Example 10(b), to give 187 mg of the title compound as a powder, at softening 144°-146° C.

Sources & evidence

ORD record: ord-7d5194ce2b954c119fd07075c5e89964
Source dataset: uspto-grants-1995_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05459148

Reaction notes

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