Sodium Hydroxide → HCID 15293911, compound

HRID 2210574Notes

Reaction equation

HRID 2210574 reaction equation
[CH2:1]([C:5]1[N:6]([CH2:18][C:19]2[CH:24]=[CH:23][C:22]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=3[C:31]([C:33]([O:35]C)=[O:34])=[O:32])=[CH:21][CH:20]=2)[C:7]([C:16]#[N:17])=[C:8]([CH:10]([OH:15])[C:11]([CH3:14])([CH3:13])[CH3:12])[N:9]=1)[CH2:2][CH2:3][CH3:4].[OH-:37].[Na+]>>[CH2:1]([C:5]1[N:6]([CH2:18][C:19]2[CH:24]=[CH:23][C:22]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=3[C:31]([C:33]([OH:35])=[O:34])=[O:32])=[CH:21][CH:20]=2)[C:7]([C:16]([NH2:17])=[O:37])=[C:8]([CH:10]([OH:15])[C:11]([CH3:12])([CH3:14])[CH3:13])[N:9]=1)[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 19378951HCID 19378951, compound

Product 1

HCID 15293911HCID 15293911, compound

Procedure

335 mg of 2-butyl-4-(1-hydroxy-2,2-dimethylpropyl)-1-[(2'-methoxalylbiphenyl-4-yl)methyl]imidazole-5-carbonitrile [prepared as described in step (a) above] were subjected to hydrolysis using 7 ml of a 1N aqueous solution of sodium hydroxide in the same manner as described in Example 10(b), to give 256 mg of the title compound as a crystalline powder, melting at 192°-194° C. (with decomposition).

Sources & evidence

ORD record
ord-a68ed28ab57349e7bef55ceaee5cf836
Source dataset
uspto-grants-1995_10
Patent number
US05459148

Reaction notes

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