Hydrochloric Acid → HCID 67624709, compound

HRID 2210577Notes

Reaction equation

HRID 2210577 reaction equation
C(O[C:6]([N:8]([CH2:10][C:11]1[N:12]([CH2:23][C:24]2[CH:29]=[CH:28][C:27]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][C:31]=3[C:36]([C:38]([OH:40])=[O:39])=[O:37])=[CH:26][CH:25]=2)[C:13]([C:20]([OH:22])=[O:21])=[C:14]([C:16]([OH:19])([CH3:18])[CH3:17])[N:15]=1)C)=O)(C)(C)C.[ClH:41]>O1CCOCC1>[ClH:41].[OH:19][C:16]([C:14]1[N:15]=[C:11]([CH2:10][NH:8][CH3:6])[N:12]([CH2:23][C:24]2[CH:25]=[CH:26][C:27]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][C:31]=3[C:36]([C:38]([OH:40])=[O:39])=[O:37])=[CH:28][CH:29]=2)[C:13]=1[C:20]([OH:22])=[O:21])([CH3:17])[CH3:18]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 19378943HCID 19378943, compound

Product 1

HCID 67624709HCID 67624709, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

339 mg of 2-(N-t-Butoxycarbonyl-N-methylaminomethyl)-4-(1-hydroxy-1-methylethyl)-1-[(2'-oxalobiphenyl-4-yl) methyl]imidazole-5-carboxylic acid [prepared as described in step (b) above] were subjected to de-t-butoxycarbonylation using 3 ml of a 4N solution of hydrogen chloride in dioxane in the same manner as described in Example 3(b), to give 260 mg of the title compound, melting at 172°-175° C. (with decomposition).

Sources & evidence

ORD record
ord-74549868759743d7a062b72e1b2e2ad8
Source dataset
uspto-grants-1995_10
Patent number
US05459148

Reaction notes

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