反应详情

Formic acid (17 g, 378 mmol) and acetic anhydride (13 g, 126 mmol) where combined at 10° C. A slurry of 2-(3-pyridinyl)-5,5-dimethyl-4-thiazolidinecarboxylic acid (10 g, 42 mmol), Prepared as in step 1, in THF (250 mL) was added over five minutes. The resulting clear-yellow solution was wanted slowly to ambient temperature and stirred for 17 hours, during which time it became a white suspension. The THF was removed in vacuo, and the resulting slurry was filtered to yield a white solid. The solid was rinsed with ether to give 2-(3-pyridinyl)-3-formyl-5,5-dimethyl-4-thiazolidinecarboxylic acid (10 g) which was used without further purification.

1. customcombined at 10° C
2. customwas wanted slowly to ambient temperature
3. customThe THF was removed in vacuo
4. filtrationthe resulting slurry was filtered
5. customto yield a white solid
6. washThe solid was rinsed with ether