Triethylamine → HCID 15289041, compound

HRID 2210634Notes

Reaction equation

HRID 2210634 reaction equation
[C:1]([O:4][C@@H:5]1[C@H:9]([O:10][C:11](=[O:13])[CH3:12])[C@@H:8]([CH2:14][O:15][C:16](=[O:18])[CH3:17])[O:7][C@H:6]1[N:19]1[CH:27]=[N:26][C:25]2[C:20]1=[N:21][C:22](I)=[N:23][C:24]=2[Cl:28])(=[O:3])[CH3:2].C(N(CC)CC)C.[CH:37]#[C:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH2:44][CH3:45]>O1CCOCC1.Cl[Pd](Cl)([P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1>[C:1]([O:4][C@@H:5]1[C@H:9]([O:10][C:11](=[O:13])[CH3:12])[C@@H:8]([CH2:14][O:15][C:16](=[O:18])[CH3:17])[O:7][C@H:6]1[N:19]1[CH:27]=[N:26][C:25]2[C:20]1=[N:21][C:22]([C:37]#[C:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH2:44][CH3:45])=[N:23][C:24]=2[Cl:28])(=[O:3])[CH3:2]

Participants

6

Reactant 3

HCID 8471TriethylamineHCID 189371-NonyneHCID 482588Acetic acid (2R,3R,4R,5R)-3,4-diacetoxy-5-(6-chloro-2-iodo-purin-9-YL)-tetrahydro-furan-2-ylmethyl ester

Product 1

HCID 15289041HCID 15289041, compoundYield 89%

Reagents, catalysts & solvents 2

HCID 178418476HCID 178418476, compoundCatalystHCID 312751,4-DioxaneSolvent

Procedure

In 12 ml of 1,4-dioxane were suspended 2.15 g (4 mmole ) of 9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-6- chloro-2-iodopurine , 56 mg (0.08 mmole) of bis(triphenylphosphine)palladium dichloride and 15 mg (0.08 mmole ) of cuprous iodide, and 1.2 ml of triethylamine and 0.75 ml of 1-nonyne were added to the suspension. The mixture was stirred and caused to react at room temperature (25° C.) for 12 hours. The reaction solution at this time had a transparent pale brown color, which was paler than those in the aforementioned (i) or (ii). After the reaction, the solution was concentrated, and 200 ml of ethyl acetate was added to the residue to obtain a solution, which was distributed and washed several times with an aqueous EDTA.2Na solution and a saturated brine solution, respectively to remove copper ions. The organic layer was subjected to silica gel column chromatography in the same manner as in (i) to remove colored materials and other by-products and to produce 1.90 g (yield 89%) of 9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-6-chloro-2-(1-nonynyl)purine as a viscous material.

Workup

  1. additionwere added to the suspension
  2. customto react at room temperature (25° C.) for 12 hours
  3. customAfter the reaction
  4. concentrationthe solution was concentrated
  5. addition200 ml of ethyl acetate was added to the residue
  6. customto obtain a solution, which
  7. washwashed several times with an aqueous EDTA
  8. custom2Na solution and a saturated brine solution, respectively to remove copper ions
  9. customto remove colored materials and other by-products

Sources & evidence

ORD record
ord-dbba6ef7a5b6483bb93315f93211b0d2
Source dataset
uspto-grants-1995_10
Patent number
US05459254

Reaction notes

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