Hydrochloric Acid → HCID 19379330, compound

HRID 2210681Notes

Reaction equation

HRID 2210681 reaction equation
[ClH:1].[NH2:2][CH:3]([CH:7]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:4]([OH:6])=[O:5].Cl.[CH3:21]O>>[ClH:1].[NH2:2][CH:3]([CH:7]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:4]([O:6][CH3:21])=[O:5]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 197724602-Amino-3,3-diphenylpropanoic acid hydrochloride

Product 1

HCID 19379330HCID 19379330, compound

Procedure

Through a solution of 2-amino-3,3-diphenylpropanoic acid hydrochloride (35.0 g, 126 mmol) in methanol (500 ml) was bubbled hydrogen chloride for 3 h. The solution was stirred at room temperature for 120 h and the solvent removed in vacuo. Addition of diethyl ether gave methyl 2-amino-3,3-diphenylpropanoate hydrochloride, m.p.=213°-215° C.(dec.). 1H NMR (360 MHz, DMSO-d6) δ8.70 (3H, vbs), 7.20-7.57 (10H, m), 4.94 (1H, d, J=11 Hz), 4.36 (1H, d, J=11 Hz), 3.39 (3H, s). m/z (CI+) 256(MH).

Workup

  1. customthe solvent removed in vacuo
  2. additionAddition of diethyl ether

Sources & evidence

ORD record
ord-cb207170e4524f6ead12731406ebb839
Source dataset
uspto-grants-1995_10
Patent number
US05459270

Reaction notes

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