反应详情

A mixture of 14.0 g (0.057 mole) 3-(3-bromopropyl)benzamide (the product of step (d)), 11.5 g potassium phthalimide and 26.3 ml dimethylformamide was heated to reflux under argon gas for four hours. The heat source was removed and the mixture was stirred to cool to room temperature. Water (about 85 ml) was added. The resulting slurry was stirred for 20 minutes, then filtered and washed three times with about 50 ml cold water (each wash made a slurry solution in the funnel). The solids were then washed with about 20 ml cold 1:1 isopropyl alcohol: water and dried under vacuum overnight to give 17.04 g of the above-identified product.

1. temperaturewas heated
2. temperatureto reflux under argon gas for four hours
3. customThe heat source was removed
4. additionWater (about 85 ml) was added
5. stirringThe resulting slurry was stirred for 20 minutes
6. filtrationfiltered
7. washwashed three times with about 50 ml cold water (each wash
8. washThe solids were then washed with about 20 ml cold 1:1 isopropyl alcohol
9. dry with materialwater and dried under vacuum overnight