反应详情

16-Hydroxyhexadecanoic acid (0.5 g) was suspended in methylene chloride (15 ml), and triethylamine (1.03 ml) was added to the suspension. To the mixture, while ice-cooled and stirred, was added dropwise acetyl chloride (0.39 ml). After 8 hours ice was added, and extracted with chloroform. The chloroform layer was washed with a saturated sodium hydrogen carbonate solution and then twice with water and dried with anhydrous sodium sulfate. The chloroform layer was concentrated and the residue thus obtained was subjected to chromatography on a silica gel column with an eluent system of chloroform-hexane (2:1) to give 16-acetoxyhexadecanoic acid (0.58 g).

1. temperatureTo the mixture, while ice-cooled
2. additionAfter 8 hours ice was added
3. extractionextracted with chloroform
4. washThe chloroform layer was washed with a saturated sodium hydrogen carbonate solution
5. dry with materialtwice with water and dried with anhydrous sodium sulfate
6. concentrationThe chloroform layer was concentrated
7. customthe residue thus obtained