5-Methoxy-1-benzothiophene → 5-Bromo-2-chloro-1-(5-methoxybenzo[b]thiophen-2-ylmethyl)benzene

HRID 221086Notes

Reaction equation

HRID 221086 reaction equation
[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:6]2[S:7][CH:8]=[CH:9][C:5]=2[CH:4]=1.[Br:12][C:13]1[CH:14]=[CH:15][C:16]([Cl:21])=[C:17]([CH:20]=1)[CH:18]=O>>[Br:12][C:13]1[CH:14]=[CH:15][C:16]([Cl:21])=[C:17]([CH2:18][C:8]2[S:7][C:6]3[CH:10]=[CH:11][C:3]([O:2][CH3:1])=[CH:4][C:5]=3[CH:9]=2)[CH:20]=1

Participants

3

Reactant 2

HCID 36324255-Methoxy-1-benzothiopheneHCID 106089255-Bromo-2-chlorobenzaldehyde

Product 1

HCID 666075985-Bromo-2-chloro-1-(5-methoxybenzo[b]thiophen-2-ylmethyl)benzene

Procedure

5-Methoxybenzo[b]thiophene (see WO 97/25033) and 5-bromo-2-chlorobenzaldehyde obtained in Reference Example 16-(1) were treated in a manner similar to Reference Example 9 to give the target compound. APCI-Mass m/Z 367/369 (M+H).

Workup

  1. additionwere treated in a manner similar to Reference Example 9
  2. customto give the target compound

Sources & evidence

ORD record
ord-0e4678f55c5145ea9411cc571e4accd4
Source dataset
uspto-grants-2012_06
Patent number
US08202984B2

Reaction notes

Loading…