反应详情

165 mg of diphenylmethyl 7-amino-3-(benzothiazol-2-yl)thio-3-cephem-4-carboxylate as synthesized in the same manner as in Example 1 (b) above were dissolved in 4 ml of methylene chloride, and to the resulting solution were added 243 mg of (Z)-2-(2-tritylaminothiazol-4-yl)-2-diphenylmethoxycarbonylmethoxyiminoacetic acid, 0.10 of pyridine and 35 μl of phosphorus oxychloride. Next, the acylation reaction and the post-treatment of the reaction solution were carried out in the same manner as in Example 1 (b), and the resultant residue was then purified through a column chromatography on 30 g of silica gel (as developed with mixed solvents of toluene and ethyl acetate, 10:1) to afford 260 mg of the titled compound (yield, 73%).

1. customNext, the acylation reaction
2. customthe resultant residue was then purified through a column chromatography on 30 g of silica gel (as developed with mixed solvents of toluene and ethyl acetate, 10:1)