Hydrochloric Acid → HCID 53666096, compound

HRID 22110Notes

Reaction equation

HRID 22110 reaction equation
C([NH:4][CH:5]1[CH2:13][C:12]2[C:7](=[CH:8][CH:9]=[C:10]([C:14]3[C:19]([C:20]([C:22]4[C:23]([C:28]5[CH:29]=[C:30]6[C:34](=[CH:35][CH:36]=5)[CH2:33][CH:32]([NH:37]C(=O)C)[CH2:31]6)=[N:24][CH:25]=[CH:26][CH:27]=4)=[O:21])=[CH:18][CH:17]=[CH:16][N:15]=3)[CH:11]=2)[CH2:6]1)(=O)C.Cl>>[NH2:37][CH:32]1[CH2:31][C:30]2[C:34](=[CH:35][CH:36]=[C:28]([C:23]3[C:22]([C:20]([C:19]4[C:14]([C:10]5[CH:11]=[C:12]6[C:7](=[CH:8][CH:9]=5)[CH2:6][CH:5]([NH2:4])[CH2:13]6)=[N:15][CH:16]=[CH:17][CH:18]=4)=[O:21])=[CH:27][CH:26]=[CH:25][N:24]=3)[CH:29]=2)[CH2:33]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 544891472-Acetylamino-indan-5-yl-3-pyridyl ketone

Product 1

HCID 53666096HCID 53666096, compound

Procedure

51 g of 2-acetylamino-indan-5-yl-3-pyridyl ketone are refluxed for 16 hours with 250 ml of half concentrated hydrochloric acid. The solution is concentrated and then adjusted to pH 12 using 15N sodium hydroxide solution. The precipitate formed is washed with water and recrystallised from 100 ml of isopropanol.

Workup

  1. concentrationThe solution is concentrated
  2. customThe precipitate formed
  3. washis washed with water
  4. customrecrystallised from 100 ml of isopropanol

Sources & evidence

ORD record
ord-e55b20c4b4a44569990dfa163a9e3871
Source dataset
uspto-grants-1995_06
Patent number
US05426119

Reaction notes

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