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HRID2211022

反应详情

EQUATION

反应方程式

HRID 2211022 的结构方程式

REACTANTS

反应物

5
结构：N=C(N)N
HCID3520

Guanidine

CH5N3

结构：CS(=O)(=O)c1cc(C(=O)O)ccc1Cl
HCID182670

4-Chloro-3-(methanesulfonyl)benzoato

C8H7ClO4S

结构：CC(C)(C)OC(=O)C1CCN(N)CC1
HCID21899493

未命名化合物

结构：COC(=O)c1ccc(N2CCC(C(=O)OC(C)(C)C)CC2N)c(S(C)(=O)=O)c1
HCID67789530

未命名化合物

结构：CI.O=C([O-])[O-].[K+].[K+]
HCID86747754

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)C1CCN(c2ccc(C(=O)N=C(N)N)cc2S(C)(=O)=O)C(N)C1
HCID70199108

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
结构：CO
溶剂HCID887

Methanol

CH4O

结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

A solution of 550 mg of methyl 3-methylsulphonyl-4-(4-BOC-aminopiperidino)benzoate (m.p. 149°-150°) [obtainable by reacting 3-methylsulphonyl-4-chlorobenzoic acid with 4-BOC-aminopiperidine in a melt and subsequently esterifying the product with methyl iodide/K2CO3 in dimethylformamide (DMF)] and 383 mg of guanidine in 6 ml of methanol (abs.) is stirred at 60° for a period of 45 min. After removing the solvent, and after customary working-up, N-diaminomethylene-3-methylsulphonyl-4-(4-BOC-aminopiperidino)benzamide is obtained, m.p. 224°-226°.

WORKUP

后处理

  1. customAfter removing the solvent