HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Guanidine → N-diaminomethylene-3-methylsulphonyl-4-(4-BOC-aminopiperidino)benzamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Guanidine | HCID 3520 | — |
| Edukt | 4-Chloro-3-methanesulfonylbenzoic acid | HCID 182670 | — |
| Edukt | Tert-butyl 1-aminopiperidine-4-carboxylate | HCID 21899493 | — |
| Edukt | methyl 3-methylsulphonyl-4-(4-BOC-aminopiperidino)benzoate | HCID 67789530 | — |
| Edukt | Methyl iodide potassium carbonate | HCID 86747754 | — |
| Lösungsmittel | Methanol | HCID 887 | — |
| Lösungsmittel | Dimethylformamide | HCID 6228 | — |
| Produkt | N-diaminomethylene-3-methylsulphonyl-4-(4-BOC-aminopiperidino)benzamide | HCID 70199108 | — |
Reaktionsschritte
A solution of 550 mg of methyl 3-methylsulphonyl-4-(4-BOC-aminopiperidino)benzoate (m.p. 149°-150°) [obtainable by reacting 3-methylsulphonyl-4-chlorobenzoic acid with 4-BOC-aminopiperidine in a melt and subsequently esterifying the product with methyl iodide/K2CO3 in dimethylformamide (DMF)] and 383 mg of guanidine in 6 ml of methanol (abs.) is stirred at 60° for a period of 45 min. After removing the solvent, and after customary working-up, N-diaminomethylene-3-methylsulphonyl-4-(4-BOC-aminopiperidino)benzamide is obtained, m.p. 224°-226°.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05461066 |
| Quelldatensatz | uspto-grants-1995_10 |
| ORD ID | ord-8cd4a23add3845eab74d9bb8a00b27c6 |
| Quellennotiz | uspto-grants-1995_10 |