Hydrazine hydrate (1:1) → HCID 10263181, compound

HRID 2211097Notes

Reaction equation

HRID 2211097 reaction equation
[CH:1]1([C:7]([C:9]2[CH:17]=[CH:16][CH:15]=[CH:14][C:10]=2[C:11](O)=[O:12])=O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.O.[NH2:19][NH2:20]>C(O)C>[CH:1]1([C:7]2[C:9]3[C:10](=[CH:14][CH:15]=[CH:16][CH:17]=3)[C:11](=[O:12])[NH:20][N:19]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 10421448HCID 10421448, compound

Product 1

HCID 10263181HCID 10263181, compoundYield 63.6%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

12.0 g of o-(cyclohexanoyl) benzoic acid and 3.1 g of hydrazine hydrate were dissolved in 60 ml of ethanol, and the solution was refluxed for 4 hours. Ethanol was distilled off and the remaining solution was crystallized by adding ether, thereby obtaining 7.5 g of 4-cyclohexyl-1-phthalazinone.

Workup

  1. temperaturethe solution was refluxed for 4 hours
  2. distillationEthanol was distilled off
  3. customthe remaining solution was crystallized
  4. additionby adding ether

Sources & evidence

ORD record
ord-577f1b64be0b4af78476a9ba2c7b0f1b
Source dataset
uspto-grants-1995_10
Patent number
US05462941

Reaction notes

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