Ethanol → HCID 19375610, compound

HRID 2211104Notes

Reaction equation

HRID 2211104 reaction equation
[Br:1][C:2]1[S:6][C:5]([C:7]([C:9]2[CH:17]=[CH:16][CH:15]=[CH:14][C:10]=2[C:11](O)=O)=O)=[CH:4][CH:3]=1.[OH2:18].[NH2:19][NH2:20].[CH2:21](O)C>>[Br:1][C:2]1[S:6][C:5]([C:7]2[C:9]3[C:10](=[CH:14][CH:15]=[CH:16][CH:17]=3)[C:11](=[O:18])[NH:20][N:19]=2)=[CH:4][C:3]=1[CH3:21]

Participants

4

Reactant 3

HCID 702EthanolHCID 24654Hydrazine hydrate (1:1)HCID 52606402-[(5-bromo-2-thienyl)carbonyl]benzenecarboxylic acid

Product 1

HCID 19375610HCID 19375610, compound

Procedure

1.70 g of o-(5-bromo-2-thenoyl)benzoic acid and hydrazine hydrate were dissolved in 40 ml of ethanol, and the solution was refluxed for 4 hours. After cooling the solution, it was crystallized by adding ether, thereby obtaining 315 mg of 4-(5-bromo-4-methyl-2-thienyl)-1-phthalazinone.

Workup

  1. temperaturethe solution was refluxed for 4 hours
  2. temperatureAfter cooling the solution, it
  3. customwas crystallized
  4. additionby adding ether

Sources & evidence

ORD record
ord-1215ae1a8a2d48fe89765e2faef66d4f
Source dataset
uspto-grants-1995_10
Patent number
US05462941

Reaction notes

Loading…