Hydrochloric Acid → 4-(4- methylthiophen-2-yl)phthalazin-1(2H)-one

Participants

Reaction Steps

300 mg of 4-(5-bromo-4-methyl-2-thienyl)-1-phthalazinone, 500 mg of 5% palladium carbon (Pd-C) and 1 ml of concentrated hydrochloric acid were added to 50 ml of ethanol, and hydrogen gas was reacted with the resulting mixture under ordinary pressure. After the end of the reaction, the mixture was filtered, and the filtrate was concentrated to obtain 205 mg of 4-(4-methyl-2-thienyl)phthalazinone.

Provenance & Evidence