Hydrochloric Acid → 4-(4- methylthiophen-2-yl)phthalazin-1(2H)-one

HRID 2211105Notes

Reaction equation

HRID 2211105 reaction equation
Br[C:2]1[S:6][C:5]([C:7]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[C:10](=[O:17])[NH:9][N:8]=2)=[CH:4][C:3]=1[CH3:18].Cl.[H][H]>[C].[Pd].C(O)C>[CH3:18][C:3]1[CH:4]=[C:5]([C:7]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[C:10](=[O:17])[NH:9][N:8]=2)[S:6][CH:2]=1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 19375610HCID 19375610, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 510510764-(4- methylthiophen-2-yl)phthalazin-1(2H)-oneYield 90.6%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

300 mg of 4-(5-bromo-4-methyl-2-thienyl)-1-phthalazinone, 500 mg of 5% palladium carbon (Pd-C) and 1 ml of concentrated hydrochloric acid were added to 50 ml of ethanol, and hydrogen gas was reacted with the resulting mixture under ordinary pressure. After the end of the reaction, the mixture was filtered, and the filtrate was concentrated to obtain 205 mg of 4-(4-methyl-2-thienyl)phthalazinone.

Workup

  1. customwas reacted with the resulting mixture under ordinary pressure
  2. customAfter the end of the reaction
  3. filtrationthe mixture was filtered
  4. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-323656749c4c4cd0876c830aff5601e9
Source dataset
uspto-grants-1995_10
Patent number
US05462941

Reaction notes

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