HCID 19375609, compound → HCID 53924080, compound

HRID 2211107Notes

Reaction equation

HRID 2211107 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([C:12]2[S:13][CH:14]=[C:15]([CH3:17])[CH:16]=2)=[N:4][N:3]=1>CN1CCCC1=O>[C:6]1([C@H:5]([NH:4][C:2]2[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]([C:12]3[S:13][CH:14]=[C:15]([CH3:17])[CH:16]=3)=[N:4][N:3]=2)[CH3:12])[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

Participants

3

Reactant 1

HCID 19375609HCID 19375609, compound

Product 1

HCID 53924080HCID 53924080, compoundYield 18.9%

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Conditions

Temperature
140 °C

Procedure

200 mg of 1-chloro-4-(4-methyl-2-thienyl)phthalazine and 100 mg of D-α-phenylethylamine were dissolved in 2 ml of N-methylpyrrolidone, and the solution was stirred at 140° C. for 8 hours. After the solution was subjected to after-treatment, it was purified by column chromatography, thereby obtaining 25 mg of (R)-1-(α-phenylethylamino)-4-(4-methyl-2-thienyl)phthalazine.

Workup

  1. customwas purified by column chromatography

Sources & evidence

ORD record
ord-6249c61d76694245b130da34f87d16de
Source dataset
uspto-grants-1995_10
Patent number
US05462941

Reaction notes

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