Hydrazine hydrate (1:1) → HCID 19375604, compound

HRID 2211114Notes

Reaction equation

HRID 2211114 reaction equation
[C:1]1([C:6]([C:8]2[S:9][CH:10]=[CH:11][C:12]=2[C:13]([OH:15])=O)=O)[S:5][CH:4]=[CH:3][CH:2]=1.O.[NH2:17][NH2:18]>C(O)C>[S:5]1[CH:4]=[CH:3][CH:2]=[C:1]1[C:6]1[C:8]2[S:9][CH:10]=[CH:11][C:12]=2[C:13](=[O:15])[NH:18][N:17]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 19375602HCID 19375602, compound

Product 1

HCID 19375604HCID 19375604, compoundYield 88.6%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

0.70 g of 2-(2-thenoyl)-3-thiophene carboxylic acid and 0.22 g of hydrazine hydrate were dissolved in 20 ml of ethanol, and the solution was refluxed for 5 hours. After cooling the solution, it was crystallized by adding ether, thereby obtaining 0.61 g of 7-(2-thienyl)thieno[2,3-d]-pyridazine-4(5H)-one.

Workup

  1. temperaturethe solution was refluxed for 5 hours
  2. temperatureAfter cooling the solution, it
  3. customwas crystallized
  4. additionby adding ether

Sources & evidence

ORD record
ord-d21fe2f998c74c58a456d3a29be0d5f3
Source dataset
uspto-grants-1995_10
Patent number
US05462941

Reaction notes

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