反应详情

温度

100 °C

0.15 g of 7-phenyl-furano[2,3-d]pyridazine-4-(5H)-one and 10 ml of phosphorus oxychloride were dissolved in 10 ml of dichloroethane, and the solution was stirred at 100° C. for 3 hours. The reaction solution was concentrated, and a 1-N aqueous KOH solution was added thereto under cooling with ice. The solution was extracted with chloroform and dried. The solvent was distilled off, thereby obtaining 0.10 g of 4-chloro-7-phenyl-furano[2,3-d]pyridazine.

1. concentrationThe reaction solution was concentrated
2. additiona 1-N aqueous KOH solution was added
3. temperatureunder cooling with ice
4. extractionThe solution was extracted with chloroform
5. customdried
6. distillationThe solvent was distilled off