Potassium Hydroxide → (R)-4-(1-cyclohexylethylamino)-7-phenyl-furano[2,3-d]pyridazine

HRID 2211118Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2211118
Cl[C:2]1[N:7]=[N:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[C:4]2[O:14][CH:15]=[CH:16][C:3]=12.[CH:17]1([C@H:23]([NH2:25])[CH3:24])[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1.[OH-].[K+]>CN1CCCC1=O>[CH:17]1([C@H:23]([NH:25][C:2]2[N:7]=[N:6][C:5]([C:8]3[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=3)=[C:4]3[O:14][CH:15]=[CH:16][C:3]=23)[CH3:24])[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1

Komponenten

5

Edukt 3

HCID 14797Potassium HydroxideHCID 10997046(1R)-1-CyclohexylethanamineHCID 856965044-Chloro-7-phenyl-furano[2,3-d]pyridazine

Produkt 1

HCID 67624038(R)-4-(1-cyclohexylethylamino)-7-phenyl-furano[2,3-d]pyridazineAusbeute 43,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 13387N-methyl-2-pyrrolidoneLösungsmittel

Reaktionsbedingungen

Temperatur
140 °C

Versuchsvorschrift

0.10 g of 4-chloro-7-phenyl-furano[2,3-d]pyridazine and 0.165 g of (R)-1-cyclohexylethylamine was dissolved in 1 ml of N-methylpyrrolidone, and the solution was stirred at 140° C. for 6 hours. After cooling the solution, an aqueous 5% KOH solution was added thereto, and the solution was extracted with chloroform. By purifying the extract by silica gel chromatography, 0.061 g of (R)-4-(1-cyclohexylethylamino)-7-phenyl-furano[2,3-d]pyridazine was obtained.

Aufarbeitung

  1. temperatureAfter cooling the solution
  2. extractionthe solution was extracted with chloroform
  3. customBy purifying the
  4. extractionextract by silica gel chromatography

Quellen und Nachweise

ORD-Eintrag
ord-2d16f55d2c904c47a3c54c39a57f7a9a
Quelldatensatz
uspto-grants-1995_10
Patentnummer
US05462941

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