Potassium Hydroxide → (R)-4-(1-cyclohexylethylamino)-7-phenyl-furano[2,3-d]pyridazine

Participants

Role	Name	HCID	Charge
Reactant	Potassium Hydroxide	HCID 14797	—
Reactant	(1R)-1-Cyclohexylethanamine	HCID 10997046	—
Reactant	4-Chloro-7-phenyl-furano[2,3-d]pyridazine	HCID 85696504	—
Solvent	N-methyl-2-pyrrolidone	HCID 13387	—
Product	(R)-4-(1-cyclohexylethylamino)-7-phenyl-furano[2,3-d]pyridazine	HCID 67624038	43.8%

Reaction Conditions

Temperature	140 °C

Reaction Steps

0.10 g of 4-chloro-7-phenyl-furano[2,3-d]pyridazine and 0.165 g of (R)-1-cyclohexylethylamine was dissolved in 1 ml of N-methylpyrrolidone, and the solution was stirred at 140° C. for 6 hours. After cooling the solution, an aqueous 5% KOH solution was added thereto, and the solution was extracted with chloroform. By purifying the extract by silica gel chromatography, 0.061 g of (R)-4-(1-cyclohexylethylamino)-7-phenyl-furano[2,3-d]pyridazine was obtained.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05462941
Source dataset	uspto-grants-1995_10
ORD ID	ord-2d16f55d2c904c47a3c54c39a57f7a9a
Source note	uspto-grants-1995_10