5-(4-Chlorophenyl)-2-furaldehyde → HCID 19375563, compound

Participants

Reaction Steps

A solution of 1-amino-3-[4-(4-methyl-1-piperazinyl)butyl]-2,4-imidazolidinedione, hydrochloride (0.0094 mole), dimethylformamide (75 ml) and 5-(4-chlorophenyl)-2-furancarbox aldehyde [prepared as described in U.S. Pat. No. 4,882,354, to Huang et al., assigned to Norwich Eaton Pharmaceuticals, Inc., issued Nov. 21, 1984; see Cols. 7 and 8 hereby incorporated by reference herein] (1.94 g, 0.0094 mole) is stirred at ambient temperature for 72 hours. The mixture is filtered, collecting the solid. Recrystallization from absolute ethanol/H2O and air-drying gives 2.63 g (0.0050 mole) of 1-[[[5-(4-chlorophenyl)-2-furanyl]methylene]amino]3-[4-methyl-1-piperazinyl)butyl]-2,4-imidazolidinedione dihydrochloride.

Provenance & Evidence