5-(4-Chlorophenyl)-2-furaldehyde → HCID 19375563, compound

HRID 2211135Notes

Reaction equation

HRID 2211135 reaction equation
[ClH:1].N[N:3]1[CH2:7][C:6](=[O:8])[N:5](CCCCN2CCN(C)CC2)[C:4]1=[O:20].[Cl:21]C1C=CC(C2OC(C=O)=CC=2)=CC=1>CN(C)C=O>[ClH:21].[ClH:1].[NH:3]1[CH2:7][C:6](=[O:8])[NH:5][C:4]1=[O:20]

Participants

4

Reactant 2

HCID 6761845-(4-Chlorophenyl)-2-furaldehydeHCID 19375560HCID 19375560, compound

Product 1

HCID 19375563HCID 19375563, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A solution of 1-amino-3-[4-(4-methyl-1-piperazinyl)butyl]-2,4-imidazolidinedione, hydrochloride (0.0094 mole), dimethylformamide (75 ml) and 5-(4-chlorophenyl)-2-furancarbox aldehyde [prepared as described in U.S. Pat. No. 4,882,354, to Huang et al., assigned to Norwich Eaton Pharmaceuticals, Inc., issued Nov. 21, 1984; see Cols. 7 and 8 hereby incorporated by reference herein] (1.94 g, 0.0094 mole) is stirred at ambient temperature for 72 hours. The mixture is filtered, collecting the solid. Recrystallization from absolute ethanol/H2O and air-drying gives 2.63 g (0.0050 mole) of 1-[[[5-(4-chlorophenyl)-2-furanyl]methylene]amino]3-[4-methyl-1-piperazinyl)butyl]-2,4-imidazolidinedione dihydrochloride.

Workup

  1. filtrationThe mixture is filtered
  2. customcollecting the solid
  3. customRecrystallization from absolute ethanol/H2O
  4. customair-drying

Sources & evidence

ORD record
ord-cbb9b6ecbd2a4d7886ba39ff10a4679f
Source dataset
uspto-grants-1995_10
Patent number
US05462940

Reaction notes

Loading…