2-(5-Bromopentyl)-1H-1lambda~6~,2-benzothiazole-1,1,3(2H)-trione → HCID 131719169, compound

HRID 2211144Notes

Reaction equation

HRID 2211144 reaction equation
[ClH:1].Cl.Br[C:4]1[CH:5]=[C:6]([N:14]2[CH2:19][CH2:18][N:17](CCCCN3C(=O)C4C=CC=CC=4S3(=O)=O)[CH2:16][CH2:15]2)[C:7]2[O:12][CH2:11][CH2:10][O:9][C:8]=2[CH:13]=1.Br[CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][N:42]1[C:46](=[O:47])[C:45]2[CH:48]=[CH:49][CH:50]=[CH:51][C:44]=2[S:43]1(=[O:53])=[O:52]>>[ClH:1].[Cl:1][C:4]1[CH:5]=[C:6]([N:14]2[CH2:19][CH2:18][N:17]([CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][N:42]3[C:46](=[O:47])[C:45]4[CH:48]=[CH:49][CH:50]=[CH:51][C:44]=4[S:43]3(=[O:53])=[O:52])[CH2:16][CH2:15]2)[C:7]2[O:12][CH2:11][CH2:10][O:9][C:8]=2[CH:13]=1

Participants

3

Reactant 2

HCID 166380012-(5-Bromopentyl)-1H-1lambda~6~,2-benzothiazole-1,1,3(2H)-trioneHCID 131719168HCID 131719168, compound

Product 1

HCID 131719169HCID 131719169, compound

Procedure

This compound was prepared analogous to the method described for 2-(4-(4-(7-bromo-2,3-dihydro-1,4-benzodioxin-5-yl)-1-piperazinyl)-butyl)-1,2-benzisothiazole-3(2H)-one-1,1-dioxide, dihydrochloride (Example 3) using intermediate 2a (2.00 g, 6.9 mmol) and 2(5-bromopentyl)-1,2-benzisothiazole-3(2H)-one-1,1-dioxide (2.52 g, 7.6 mmol). Yield 1.40 g, m.p. 193°-5° C.

Workup

  1. customThis compound was prepared analogous to the method

Sources & evidence

ORD record
ord-88cd936bfb1b4e6da788c3ef5f824c69
Source dataset
uspto-grants-1995_10
Patent number
US05462942

Reaction notes

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