HCID 19375626, compound → HCID 131719170, compound

HRID 2211147Notes

Reaction equation

HRID 2211147 reaction equation
[ClH:1].Cl.Br[C:4]1[CH:5]=[C:6]([N:14]2[CH2:19][CH2:18][N:17]([CH2:20][CH2:21][CH2:22][CH2:23][N:24]3[C:28](=[O:29])[C:27]4[CH:30]=[CH:31][CH:32]=[CH:33][C:26]=4[S:25]3(=O)=[O:34])[CH2:16][CH2:15]2)[C:7]2[O:12][CH2:11][CH2:10][O:9][C:8]=2[CH:13]=1.[Cl:36]C1C=C(N2CCNCC2)C2OCCOC=2C=1.[Cl:53]CCCCN1C(=O)C2C=CC=CC=2S1=O>>[ClH:36].[ClH:53].[Cl:1][C:4]1[CH:5]=[C:6]([N:14]2[CH2:15][CH2:16][N:17]([CH2:20][CH2:21][CH2:22][CH2:23][N:24]3[C:28](=[O:29])[C:27]4[CH:30]=[CH:31][CH:32]=[CH:33][C:26]=4[S:25]3=[O:34])[CH2:18][CH2:19]2)[C:7]2[O:12][CH2:11][CH2:10][O:9][C:8]=2[CH:13]=1

Participants

4

Reactant 3

HCID 19375626HCID 19375626, compound2×HCID 19375641HCID 19375641, compound2×HCID 131719168HCID 131719168, compound

Product 1

HCID 131719170HCID 131719170, compoundYield 41%

Procedure

The title compound was obtained analogous to the method described for 2-(4-(4-(7-bromo-2,3-dihydro-1,4-benzodioxin-5-yl)-1-piperazinyl)-butyl)-1,2-benzisothiazole-3(2H)-one-1,1-dioxide, dihydrochloride (Example 3) using 1-(7-chloro-2,3-dihydro-1,4-benzodioxin-5-yl)piperazine (intermediate 2a) (2.50 g, 8.54 mmol) and 2-(4-chlorobutyl)-1,2-benzisothiazole-3(2H)-one-1-oxide (Intermediate 19c) (2.20 g, 8.54 mmol). Yield: 1.90 g (41%) of the title compound, m.p. 258°-60° C.

Sources & evidence

ORD record
ord-fb00afaa95cb4a988eb7f26b68fe89f4
Source dataset
uspto-grants-1995_10
Patent number
US05462942

Reaction notes

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