Sodium Carbonate → HCID 19376419, compound

HRID 2211279Notes

Reaction equation

HRID 2211279 reaction equation
[CH3:1][O:2][C:3]([CH2:5][CH2:6][C:7]1[S:8][CH:9]=[C:10]([C:12]2[CH:17]=[CH:16][C:15]([CH:18]3[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]3)=[CH:14][CH:13]=2)[N:11]=1)=[O:4].Br.C(S[C:28](=[NH:30])[NH2:29])C.C(=O)([O-])[O-].[Na+].[Na+]>CN(C)C=O>[C:28]([N:21]1[CH2:20][CH2:19][CH:18]([C:15]2[CH:16]=[CH:17][C:12]([C:10]3[N:11]=[C:7]([CH2:6][CH2:5][C:3]([O:2][CH3:1])=[O:4])[S:8][CH:9]=3)=[CH:13][CH:14]=2)[CH2:23][CH2:22]1)(=[NH:29])[NH2:30]

Participants

5

Reactant 3

HCID 10340Sodium CarbonateHCID 200213S-Ethylisothiuronium bromideHCID 19376657HCID 19376657, compound

Product 1

HCID 19376419HCID 19376419, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Prepared from 2-(2-methoxycarbonyl-ethyl)-4-[4-(4-piperidinyl)-phenyl]-thiazole and S-ethylisothiourea-hydrobromide by heating to 100° C. for 4 hours in dimethylformamide in the presence of sodium carbonate.

Sources & evidence

ORD record
ord-ae7c5f87032f4285b450d0de50691028
Source dataset
uspto-grants-1995_10
Patent number
US05463071

Reaction notes

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