Water → Acetone Cyanohydrin
Reaction equation
[CH3:1][C:2]([CH3:6])([OH:5])[C:3]#[N:4].[OH2:7]>[O-2].[O-2].[Mn+4]>[OH:5][C:2]([CH3:6])([CH3:1])[C:3]([NH2:4])=[O:7].[CH3:1][C:2]([CH3:6])([OH:5])[C:3]#[N:4]Participants
5
Reactant 2
Product 2
Reagents, catalysts & solvents 1
Procedure
It is publicly known that manganese dioxide is used as a solid catalyst in the hydration reaction of acetone cyanohydrin. According to any of the conventional processes, α-hydroxyisobutyramide is obtained by the reaction of acetone cyanohydrin with water as shown by the following reaction equation at a temperature of 40° to 100° C. in the presence of manganese-based catalyst and preferably an acetone-based solvent in a yield of 60 to 95%.
Sources & evidence
- ORD record
- ord-0be59d60def94b7b9314cfc272ecc8b1
- Source dataset
- uspto-grants-1995_10
- Patent number
- US05463123
Reaction notes
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