1,2-Dichloro-4-nitrobenzene → 2-Chloro-1-fluoro-4-nitrobenzene

Participants

Reaction Conditions

Reaction Steps

70 g of octadecyltrimethylammonium chloride are dissolved at 70° C. in 2020 g (10.5 mol) of 3,4-dichloronitrobenzene and 100 g of o-dichlorobenzene. After addition of 580 g (10 mol) of potassium fluoride, the resulting suspension is heated for 11 hours at 180° C. with stirring and under nitrogen. During this time, some of the o-dichlorobenzene is continuously distilled off. The reaction suspension is then quickly filtered off using suction, the filter cake is washed with o-dichlorobenzene and the combined filtrates are fractionated in vacuo. In this manner 1349 g (77% of theory) of 3-chloro-4-fluoronitrobenzene and 246 g of unreacted 3,4-dichloronitrobenzene are obtained.

Provenance & Evidence