HCID 10204481, compound → HCID 54418675, compound

HRID 2211399Notes

Reaction equation

HRID 2211399 reaction equation
[CH2:1]([C:3]1[CH:26]=[C:25]([C:27]2[CH:32]=[CH:31][C:30]([F:33])=[CH:29][CH:28]=2)[C:24]([OH:34])=[CH:23][C:4]=1[O:5][CH2:6][CH2:7][CH2:8][O:9][C:10]1[CH:15]=[CH:14][CH:13]=[C:12](O)[C:11]=1[CH2:17][CH2:18][C:19]([O:21]C)=[O:20])[CH3:2].C(C1C=C(C2C=CC(F)=CC=2)C(O)=CC=1OCCCOC1C=CC=C(O)C=1CCC(O)=O)C>>[F:33][C:30]1[CH:31]=[CH:32][C:27]([C:25]2[C:24]([OH:34])=[CH:23][C:4]([O:5][CH2:6][CH2:7][CH2:8][O:9][C:10]3[C:11]4[CH2:17][CH2:18][C:19](=[O:20])[O:21][C:12]=4[CH:13]=[CH:14][CH:15]=3)=[C:3]([CH2:1][CH3:2])[CH:26]=2)=[CH:28][CH:29]=1

Participants

3

Reactant 2

HCID 10204481HCID 10204481, compoundHCID 19375778HCID 19375778, compound

Product 1

HCID 54418675HCID 54418675, compound

Procedure

When methyl 3-(2-(3-(2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)-6-hydroxyphenyl)propionate (Example 12) was hydrolyzed under the conditions of Preparation 26, in addition to the desired product 3-(2-(3-(2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy)propoxy)-6-hydroxyphenyl)propionic acid (Example 13), the title product was isolated in 10% yield, as isolated by preparative reverse phase HPLC. NMR, MS. Analysis for C26H25FO5 : Calc: C, 76.55; H, 5.77; Found: C, 76.39; H, 5.92.

Sources & evidence

ORD record
ord-477d42913705459d908a20b842858f64
Source dataset
uspto-grants-1995_10
Patent number
US05462954

Reaction notes

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