HRID2211422

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID96750

5-Fluoro-1H-indole-3-acetic acid

C10H8FNO2

结构：COc1ccccc1[C@]1(O)CCC(c2ccccc2)(c2ccccc2)[C@H]2CNC[C@H]21.Cl

HCID70218598

未命名化合物

PRODUCTS

生成物

结构：COc1ccccc1[C@]1(O)CCC(c2ccccc2)(c2ccccc2)[C@H]2CN(C(=O)Cc3c[nH]c4ccc(F)cc34)C[C@H]21

HCID57167195

未命名化合物

收率 34.1%

PROCEDURE

实验过程

By working in accordance with the operating method of Use Example 4, starting from 0.8 g of (3aS, 4S, 7aS)-7,7 -diphenyl-4-(2-methoxyphenyl)-perhydroisoindol-4-ol hydrochloride and 0.39 g of (5-fluoro-3-indolyl)-acetic acid, 0.36 g of (3aS, 4S, 7aS)-7,7-diphenyl-2-[(5-fluoro-3-indolyl)-acetyl]-4-(2-methoxyphenyl)-perhydroisoindol-4-ol is obtained in the form of white crystals which melt with decomposition at 170° C.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ff5e89c93eb5493298ff940668a82b55
来源数据集: uspto-grants-1995_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05463077
来源说明: uspto-grants-1995_10

反应 SMILES

Cl.[C:2]1([C:8]2([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)[C@@H:16]3[C@@H:12]([CH2:13][NH:14][CH2:15]3)[C@@:11]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[O:24][CH3:25])([OH:17])[CH2:10][CH2:9]2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[F:32][C:33]1[CH:34]=[C:35]2[C:39](=[CH:40][CH:41]=1)[NH:38][CH:37]=[C:36]2[CH2:42][C:43](O)=[O:44]>>[C:26]1([C:8]2([C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)[C@@H:16]3[C@@H:12]([CH2:13][N:14]([C:43](=[O:44])[CH2:42][C:36]4[C:35]5[C:39](=[CH:40][CH:41]=[C:33]([F:32])[CH:34]=5)[NH:38][CH:37]=4)[CH2:15]3)[C@@:11]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[O:24][CH3:25])([OH:17])[CH2:10][CH2:9]2)[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1