5-Fluoroindole-3-acetic acid → (3aS,4S,7aS)-7,7-diphenyl-2-[(5-fluoro-3-indolyl)acetyl]-4-(2-methoxyphenyl)perhydroisoindol-4-ol

Participants

Reaction Steps

By working in accordance with the operating method of Use Example 4, starting from 0.8 g of (3aS, 4S, 7aS)-7,7 -diphenyl-4-(2-methoxyphenyl)-perhydroisoindol-4-ol hydrochloride and 0.39 g of (5-fluoro-3-indolyl)-acetic acid, 0.36 g of (3aS, 4S, 7aS)-7,7-diphenyl-2-[(5-fluoro-3-indolyl)-acetyl]-4-(2-methoxyphenyl)-perhydroisoindol-4-ol is obtained in the form of white crystals which melt with decomposition at 170° C.

Provenance & Evidence